Minoxidil & Tretinoin
RX
Strength: 7% & 0.025%
Prescription Required
Daily Serum
Why Us? We know how important absorption is without going systemic, which is why this formula combines minoxidil and tretinoin to maximize topical efficiency at the scalp.
Select Subscription Plan:
33% OFF FIRST 3 MONTHS
A licensed Mane Medical provider will review your intake to determine eligibility.
View Ingredient Safety Information
Safety Information
Before using topical minoxidil and tretinoin and each time you get a refill, please review the following important safety details. This information may be updated. It does not replace discussing your health conditions or treatment plan with your medical provider.
FDA-Approved Uses
Topical Minoxidil
Minoxidil 2% and 5% topical solutions and foams are FDA-approved for the treatment of hair loss in men and women.
Higher-strength or compounded topical formulations are prescribed off-label following an online medical evaluation.
Topical Tretinoin
Tretinoin is FDA-approved for the treatment of acne and photoaging.
When used in hair-loss formulations, tretinoin is prescribed off-label to enhance follicular penetration and activity.
What Should I Tell My Healthcare Provider Before Using This Treatment?
Please inform your clinician if any of the following apply:
Skin & Scalp History
Sensitive skin or history of dermatitis
Eczema, psoriasis, or chronic scalp irritation
Open wounds or inflamed scalp
Cardiovascular History (Minoxidil-Related)
High or low blood pressure
Heart disease
History of fainting or dizziness
Irregular heartbeat
Pregnancy & Reproductive Status
Pregnant, trying to become pregnant, or breastfeeding
(Tretinoin should not be used during pregnancy)
Medication Use
Use of other retinoids
Use of topical steroids
Use of blood-pressure medications
Who Should Not Use This Treatment?
You should not use topical minoxidil with tretinoin if you:
Have had an allergic reaction to minoxidil or tretinoin
Are pregnant or may become pregnant
Have severe or uncontrolled cardiovascular disease
Have active scalp infections or open skin lesions
Have known hypersensitivity to retinoids
Pregnancy Warning (Tretinoin)
Tretinoin may cause fetal harm. This product should not be used during pregnancy or while trying to conceive.
Possible Side Effects
Common or Mild Side Effects
Scalp redness or irritation
Dryness or flaking
Temporary burning or stinging sensation
Increased shedding during early treatment phase
Itching or tightness of the scalp
Less Common but More Serious Side Effects
Severe scalp inflammation
Swelling of face or eyelids
Allergic reactions (rash, hives, itching)
Dizziness or lightheadedness (rare, systemic absorption)
Increased sun sensitivity (tretinoin-related)
This list does not include all possible side effects, interactions, or clinical considerations. Always notify your clinician or pharmacist if you experience adverse reactions.
Photosensitivity Warning (Tretinoin)
Tretinoin increases skin sensitivity to sunlight. Use sunscreen and avoid excessive UV exposure while using this medication.
Learn More
Minoxidil clinical review:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691938/
Tretinoin clinical information:
https://www.pdr.net/drug-summary/Retin-A-tretinoin-2105
Emergency Situations
If you experience severe allergic reactions, facial swelling, difficulty breathing, fainting, or intense scalp burning, seek emergency medical care immediately.
Report adverse effects to the FDA:
www.fda.gov/medwatch
1-800-FDA-1088
Additional safety information
* This compounded topical contains FDA-approved active ingredients prescribed off-label for hair loss following an online medical evaluation. Treatment response and tolerability vary by individual.
Important Treatment Information?
Your Mane Solution
We didn't rush this.
Creating something that truly helps takes time and we took every step, researched every option, and refined every detail to make sure this would be your Mane Solution.
After hours of sweat, late nights, and relentless dedication, we’re proud to bring you our:
Minoxidil & Tretinoin Combo
Enhanced topical absorption
Tretinoin is paired with minoxidil to improve penetration at the scalp level, helping more of the active ingredient reach the follicle instead of sitting on the surface. This improves consistency and overall treatment efficiency for non-oral users.
Built for consistent compliance
This formula is designed for once-daily use with a lightweight feel that does not interfere with styling or daily routines. That makes long-term adherence easier, which is critical for maintaining results over time.
Targeted scalp-level delivery
Instead of affecting the whole body, this topical solution delivers active ingredients directly to the scalp where hair loss occurs. This allows for localized action without systemic exposure.
High-strength follicle stimulation
The 7% minoxidil concentration provides a higher-intensity stimulation signal to weakened follicles, supporting regrowth in areas affected by thinning while reinforcing existing hair.
Enhanced topical absorption
Tretinoin is paired with minoxidil to improve penetration at the scalp level, helping more of the active ingredient reach the follicle instead of sitting on the surface. This improves consistency and overall treatment efficiency for non-oral users.
Built for consistent compliance
This formula is designed for once-daily use with a lightweight feel that does not interfere with styling or daily routines. That makes long-term adherence easier, which is critical for maintaining results over time.
Targeted scalp-level delivery
Instead of affecting the whole body, this topical solution delivers active ingredients directly to the scalp where hair loss occurs. This allows for localized action without systemic exposure.
High-strength follicle stimulation
The 7% minoxidil concentration provides a higher-intensity stimulation signal to weakened follicles, supporting regrowth in areas affected by thinning while reinforcing existing hair.
The Process
01. Take the health questionnaire
02. Clinician reviews & prescribes
03. Your medication, delivered fast
Frequently Asked Questions About Oral Minoxidil
What is minoxidil?
Minoxidil is a clinically studied medication used to support hair regrowth. It works by improving blood flow to hair follicles and extending the growth phase of the hair cycle. It is available in both topical and oral forms, depending on treatment needs and medical guidance.
How long does it take for minoxidil to work?
Most patients begin noticing reduced shedding or early regrowth within 3–6 months of consistent daily use. Full visible results typically continue to improve over 6–12 months, depending on individual response.
Can minoxidil cause shedding?
Some users experience a temporary increase in shedding when starting treatment. This occurs as weaker hairs are pushed out to make room for new, stronger growth and usually resolves with continued use.
When does minoxidil shedding start?
If shedding occurs, it most often begins within the first 2–8 weeks after starting treatment. Not everyone experiences shedding, and when it does occur, it is usually temporary.
Does minoxidil cause hair loss?
No. Minoxidil does not cause permanent hair loss. Temporary shedding is part of the hair cycle reset and is a sign that follicles are responding to treatment.
What is the difference between topical and oral minoxidil?
It is important that women of child-bearing age do not take or handle Finasteride as it may cause birth defects. The most common side effects of Topical Finasteride typically occur on the scalp and may
include:
Scalp Pruritus
Burning Sensation
Irritation
Contact Dermatitis
Erythema (redness on the skin)
What are the possible side effects of minoxidil?
Minoxidil is generally well tolerated when used as directed, but side effects can occur.
Common or mild side effects may include:
Temporary increased hair shedding during the first weeks of use
Scalp irritation, redness, itching, or dryness (topical use)
Unwanted facial or body hair growth
Dizziness or lightheadedness
Mild swelling of the hands or feet (more commonly with oral use)
Less common but more serious side effects may include:
Rapid or irregular heartbeat
Chest pain
Shortness of breath
Fainting
Significant swelling of the face, hands, or legs
Severe scalp irritation or allergic reaction (rash, burning, swelling)
If you experience severe, persistent, or worsening side effects, stop using the medication and contact a licensed medical provider immediately. Seek emergency medical care for chest pain, difficulty breathing, fainting, or signs of an allergic reaction.
This information does not include all possible side effects or drug interactions. Always follow your provider’s instructions and discuss any concerns with your clinician.
How long do I need to stay on minoxidil?
Minoxidil works only while it is being used. If treatment is discontinued, hair loss may gradually resume over time. Consistent, long-term use is recommended for maintaining results.