Safety Information

Before using oral minoxidil and spironolactone and each time you get a refill, please review the following important safety details. This information may be updated. It does not replace discussing your health conditions or treatment plan with your medical provider.

FDA-Approved Uses

Oral Minoxidil
Minoxidil is FDA-approved for the treatment of high blood pressure.
Low-dose oral minoxidil is prescribed off-label for hair loss following a medical evaluation.

Oral Spironolactone
Spironolactone is FDA-approved for conditions including hypertension, heart failure, edema, and hyperaldosteronism.
It is commonly prescribed off-label for androgen-related hair loss due to its anti-androgen activity.

What Should I Tell My Healthcare Provider Before Using These Medications?

Please inform your clinician if any of the following apply:

Cardiovascular History

• High or low blood pressure

• Heart disease or heart failure

• History of fainting or dizziness

• Irregular heartbeat

Hormonal or Reproductive History

• Irregular menstrual cycles

• Polycystic ovary syndrome (PCOS)

• Actively trying to conceive

• History of hormone-related conditions

Kidney & Electrolyte Conditions

• Kidney disease

• History of high potassium levels

• Use of potassium supplements or potassium-sparing diuretics

Mental Health History

• History of depression or anxiety

• Prior mood-related side effects from medications

Other Health Considerations

• Allergy or sensitivity to minoxidil or spironolactone

• Use of blood pressure medications

• Use of other hormone-modifying therapies

Who Should Not Use These Medications?

You should not use oral minoxidil or spironolactone if you:

• Have ever had an allergic reaction to either medication

• Are pregnant, may become pregnant, or are breastfeeding

• Have severe kidney disease

• Have uncontrolled heart disease

• Have dangerously high potassium levels

• Are a child

Pregnancy Warning

Spironolactone may cause fetal harm due to its anti-androgen effects.
These medications should not be used during pregnancy or while trying to conceive.

Possible Side Effects

Common or Mild Side Effects

• Increased urination

• Dizziness or lightheadedness

• Breast tenderness

• Fatigue

• Headache

• Mild swelling of hands or feet

Less Common but More Serious Side Effects

• Irregular heartbeat

• Significant blood pressure changes

• Electrolyte imbalance (especially high potassium)

• Menstrual irregularities

• Breast enlargement

• Mood changes

• Allergic reactions (rash, swelling, itching)

This list does not include all potential side effects, interactions, or clinical considerations. Always notify your clinician or pharmacist if you experience adverse reactions.

Cardiovascular & Blood Pressure Advisory (Minoxidil)

Oral minoxidil can lower blood pressure and increase heart rate. Seek medical attention if you experience chest pain, fainting, or shortness of breath.

Electrolyte Advisory (Spironolactone)

Spironolactone can raise potassium levels. Periodic blood testing may be required to monitor kidney function and electrolyte balance.

Mental Health Advisory

If you experience new or worsening depression, anxiety, or mood changes, contact your clinician immediately.

Learn More

Minoxidil clinical review:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691938/

Spironolactone clinical information:
https://www.pdr.net/drug-summary/Aldactone-spironolactone-1824

Emergency Situations

If you experience symptoms of a severe allergic reaction, fainting, swelling of the face or throat, chest pain, or difficulty breathing, seek emergency medical care immediately.

You can report negative side effects to the FDA at:
www.fda.gov/medwatch
1-800-FDA-1088