Topical Dutasteride
RX
Strength: 0.25%
Prescription Required
Why Us? We know dutasteride requires precise control without going systemic, which is why this topical is compounded for consistent scalp-level DHT suppression.
Select Subscription Plan:
33% OFF FIRST 3 MONTHS
A licensed Mane Medical provider will review your intake to determine eligibility.
View Ingredient Safety Information
Safety Information
Before using dutasteride and each time you get a refill, please review the following important safety details. This information may be updated. It does not replace discussing your health conditions or treatment plan with your medical provider.
FDA-Approved Uses of Dutasteride
Oral Dutasteride
Dutasteride 0.5 mg is FDA-approved for the treatment of benign prostatic hyperplasia (BPH).
Topical Dutasteride
Topical and compounded forms of dutasteride are considered off-label for hair loss.
What Should I Tell My Healthcare Provider Before Using Dutasteride?
Please inform your clinician if any of the following apply:
Hormonal or Reproductive History
History of infertility
Actively trying to conceive
History of hormone-related conditions
Mental Health History
History of depression
History of anxiety disorders
Prior mood-related side effects from medications
Liver Conditions
Any history of liver disease
Any abnormal liver function tests
Other Health Considerations
Allergy or sensitivity to dutasteride
Use of other hormone-modifying medications
Who Should Not Use Dutasteride?
You should not use dutasteride if you:
Have ever had an allergic reaction to dutasteride
Are pregnant, may become pregnant, or are breastfeeding
Are a child
Have known hypersensitivity to 5-alpha reductase inhibitors
Pregnancy Warning
Dutasteride can cause abnormalities in a male fetus. Pregnant individuals should not handle crushed or broken capsules or tablets.
Possible Side Effects of Dutasteride
Common or Mild Side Effects
Reduced libido
Changes in ejaculation
Erectile difficulty
Mild fatigue
Less Common but More Serious Side Effects
Breast tenderness or enlargement
Testicular discomfort
Mood changes, including depression
Allergic reactions (rash, swelling, itching)
This list does not include all potential side effects, medication interactions, or clinical data. Always notify your clinician and or pharmacist of any side effects you experience.
Mental Health Advisory
Some patients report mood-related side effects while using dutasteride. If you experience new or worsening depression, anxiety, or mood changes, contact your clinician immediately.
Fertility Considerations
Dutasteride may affect semen parameters in a small percentage of patients. These effects are typically reversible after discontinuation. If you have concerns regarding fertility, discuss them with your clinician before starting treatment.
Learn More About Dutasteride
A detailed scientific review of dutasteride can be found here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9561294/
Additional prescriber information:
https://www.pdr.net/drug-summary/Avodart-dutasteride-935
Emergency Situations
If you experience symptoms of a severe allergic reaction, fainting, swelling of the face or throat, or severe mood changes, call 911 or seek immediate emergency medical care.
You can report negative side effects to the FDA at:
www.fda.gov/medwatch or 1-800-FDA-1088
Additional safety information
* Dutasteride is FDA-approved for BPH and prescribed off-label for hair loss following an online medical evaluation. Individual results may vary.
Important Treatment Information?
Your Mane Solution
We didn't rush this.
Creating something that truly helps takes time and we took every step, researched every option, and refined every detail to make sure this would be your Mane Solution.
After hours of sweat, late nights, and relentless dedication, we’re proud to bring you our:
Topical Dutasteride
Enhanced topical absorption
Tretinoin is paired with minoxidil to improve penetration at the scalp level, helping more of the active ingredient reach the follicle instead of sitting on the surface. This improves consistency and overall treatment efficiency for non-oral users.
Built for consistent compliance
This formula is designed for once-daily use with a lightweight feel that does not interfere with styling or daily routines. That makes long-term adherence easier, which is critical for maintaining results over time.
Targeted scalp-level delivery
Instead of affecting the whole body, this topical solution delivers active ingredients directly to the scalp where hair loss occurs. This allows for localized action without systemic exposure.
High-strength follicle stimulation
The 7% minoxidil concentration provides a higher-intensity stimulation signal to weakened follicles, supporting regrowth in areas affected by thinning while reinforcing existing hair.
Enhanced topical absorption
Tretinoin is paired with minoxidil to improve penetration at the scalp level, helping more of the active ingredient reach the follicle instead of sitting on the surface. This improves consistency and overall treatment efficiency for non-oral users.
Built for consistent compliance
This formula is designed for once-daily use with a lightweight feel that does not interfere with styling or daily routines. That makes long-term adherence easier, which is critical for maintaining results over time.
Targeted scalp-level delivery
Instead of affecting the whole body, this topical solution delivers active ingredients directly to the scalp where hair loss occurs. This allows for localized action without systemic exposure.
High-strength follicle stimulation
The 7% minoxidil concentration provides a higher-intensity stimulation signal to weakened follicles, supporting regrowth in areas affected by thinning while reinforcing existing hair.
The Process
01. Take the health questionnaire
02. Clinician reviews & prescribes
03. Your medication, delivered fast
Frequently Asked Questions About Dutasteride
What is Dutasteride?
Dutasteride is a 5-alpha-reductase inhibitor that suppresses DHT production. Unlike finasteride (which blocks only one of the 5-AR enzyme types), dutasteride blocks both Type I and Type II — acting as a more complete DHT suppressor at the root of hair loss.
Who is Dutasteride best for?
Dutasteride is ideal for users who:
Still experience hair thinning despite finasteride treatment
Want stronger DHT suppression than finasteride alone
Prefer a scalp- or topical-delivery option (if using compounded topical) to reduce systemic exposure
It is especially suited for individuals seeking maximum protection against DHT-driven follicle miniaturization.
Does Dutasteride regrow hair better than finasteride?
Dutasteride suppresses up to ~98% of circulating DHT (vs ~65–70% for finasteride), offering potentially stronger DHT blockade.
However, blocking DHT primarily helps stop further hair loss and maintain existing follicles. For regrowth of existing hair, other mechanisms (like follicle stimulation, topical absorption support) remain important.
What should I expect in terms of timeline?
DHT suppression occurs relatively quickly after consistent usage, but visible hair stabilization or regrowth may take 3–6 months or more depending on individual response and hair cycle.
As with any treatment, results vary — consistency matters most.
What are the potential side effects and risks?
Side effects of dutasteride are similar to other 5-AR inhibitors. Common or known risks may include: ISHRS+1
Reduced libido or sexual side-effects (rare)
Hormonal changes (e.g. effects on PSA levels — relevant for prostate screening) locklab.co+1
In case of topical use: possible localized irritation or sensitivity (depending on base formulation and skin type)
How do I use Dutasteride (topical or oral)?
DHT suppression occurs relatively quickly after consistent usage, but visible hair stabilization or regrowth may take 3–6 months or more depending on individual response and hair cycle.
As with any treatment, results vary — consistency matters most.
What happens if I stop treatment?
If you discontinue dutasteride, DHT production may resume — over time, this can lead to resumed miniaturization and hair shedding. Hair loss treatments like dutasteride are typically ongoing for lasting results.